Could you tell me what has happened to you?
Could you tell me what‘s wrong with you ?
补充回答：英语中what's the matter/wrong 放在疑问句中作宾语不能改成陈述句语序，其它的都要改的
what是从句的主语，引导的是宾语从句
Can you tell me what's wrong/ the matter with you?
记得采纳一个答案，让我们拿分升级，谢谢！
你不如采纳后另开一个提问，这样补充让我们很为难！
Can you tell me what is the matter with you?
（说明：宾语从句中本来都应该用陈述句语序即what the matter is；但what is the matter是特例，保持疑问句的语序。）
希望能帮到您。祝学习愉快！
Would you tell me that what is the matter ?
could you tell me what happend to you
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