This paper, from the perspective of differences between Chinese and western culture, Chinese and western trade talks to present situation analysis, first lists the differences between Chinese and western culture of the specific form of expression, and points out that the cultural differences in business negotiation failure is one of the main factors. Secondly, this paper discusses the differences between Chinese and western cultures of business negotiations influence. Finally, this paper discusses the main points of the summarized, and how to get negotiations both sides of Chinese and western successful puts forward some feasibility Suggestions.